Best peptides for cognitive function
The cognitive peptide space is dominated by two Russian-developed neuropeptides — Semax and Selank — whose evidence base is largely limited to small, non-peer-reviewed clinical studies conducted in Russia and Eastern Europe. Western literature consists primarily of animal data. We are indexing this category honestly: currently, the catalog has two peptides with documented cognitive-relevant mechanisms and some human-use data.
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Semax
Tier 3–4 — PreclinicalSemax (ACTH(4-7)PGP) is a synthetic heptapeptide derived from ACTH that upregulates BDNF (brain-derived neurotrophic factor) and other neurotrophins in animal studies. Russian clinical research reports neuroprotective effects and cognitive improvement in stroke patients, but this work has not been replicated in Western RCTs. Administered intranasally. The most studied cognitive peptide in terms of proposed mechanism.
Full Semax profile → - 2
Selank
Tier 3–4 — PreclinicalSelank is a tuftsin analog with anxiolytic properties proposed to improve learning, memory, and focus by reducing the cognitive interference of anxiety and stress. Russian small-scale trials suggest effects on anxiety and learning; Western literature is primarily animal-based. Administered intranasally. More accurately characterized as an anxiolytic-nootropic than a direct cognitive enhancer.
Full Selank profile →
We are actively expanding the cognitive peptide catalog. As new entries are indexed — including Cerebrolysin and related neuropeptides — this list will be updated. Evidence tiers and methodology are described at our methodology page.
How we evaluate evidence →